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Article

A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic.

The Journal of biological chemistry - 25 Feb 2011

Wang Jiafu, Zurawski Tomas H, Meng Jianghui, Lawrence Gary, Olango Weredeselam M, Finn David P, Wheeler Larry, Dolly J Oliver

Abstract excerpt

Blockade of neurotransmitter release by botulinum neurotoxin type A (BoNT(A)) underlies the severe neuroparalytic symptoms of human botulism, which can last a few years. The structural basis for this remarkable persistence remains unclear. Herein, recombinant BoNT(A) was found to match the neurot...

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Identifiers

PMID: 21138836
DOI: 10.1074/jbc.M110.181784
PMCID: PMC3057784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21138836-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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