Article
IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling.
Proceedings of the National Academy of Sciences of the United States of America - 25 Feb 2020
Maity Palash C, Bilal Mayas, Koning Marvyn T, Young Marc, van Bergen Cornelis A M, Renna Valerio, Nicolò Antonella, Datta Moumita, Gentner-Göbel Eva, Barendse Rob S, Somers Sebastiaan F, de Groen Ruben A L, Vermaat Joost S P, Steinbrecher Daniela, Schneider Christof, Tausch Eugen, Bittolo Tamara, Bomben Riccardo, Mazzarello Andrea Nicola, Del Poeta Giovanni, Kroes Wilma G M, van Wezel J Tom, Imkeller Katharina, Busse Christian E, Degano Massimo, Bakchoul Tamam, Schulz Axel Ronald, Mei Henrik, Ghia Paolo, Kotta Konstantia, Stamatopoulos Kostas, Wardemann Hedda, Zucchetto Antonella, Chiorazzi Nicholas, Gattei Valter, Stilgenbauer Stephan, Veelken Hendrik, Jumaa Hassan
Abstract excerpt
The prognosis of chronic lymphocytic leukemia (CLL) depends on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene. The number of IGHV mutations distinguishes mutated (M) CLL with a markedly superior prognosis from unmutated (UM) CLL cases. In addition, B cell antigen receptor (BCR) stereotypes as defined by...
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