Article
Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status.
Blood - 1 Apr 2006
Thorsélius Mia, Kröber Alexander, Murray Fiona, Thunberg Ulf, Tobin Gerard, Bühler Andreas, Kienle Dirk, Albesiano Emilia, Maffei Rossana, Dao-Ung Lan-Phuong, Wiley James, Vilpo Juhani, Laurell Anna, Merup Mats, Roos Göran, Karlsson Karin, Chiorazzi Nicholas, Marasca Roberto, Döhner Hartmut, Stilgenbauer Stephan, Rosenquist Richard
Abstract excerpt
We recently reported that Swedish VH3-21-using chronic lymphocytic leukemia (CLL) patients showed restricted immunoglobulin gene features and poor prognosis despite VH mutation status. To investigate this further, we analyzed the VH and VL gene rearrangements in 90 VH3-21+ patients from Sweden, Germany, Italy, United States, Finland, and Australia and correlated these data with survival and other prognostic...
Topics
- Amino Acid Sequence
- Australia
- Chromosome Aberrations
- Europe
- Geography
- Humans
- Immunoglobulin Fragments
- Immunoglobulin Heavy Chains