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Article

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.

The New England journal of medicine - 26 Aug 2004

Rassenti Laura Z, Huynh Lang, Toy Tracy L, Chen Liguang, Keating Michael J, Gribben John G, Neuberg Donna S, Flinn Ian W, Rai Kanti R, Byrd John C, Kay Neil E, Greaves Andrew, Weiss Arthur, Kipps Thomas J

Abstract excerpt

BACKGROUND: The course of chronic lymphocytic leukemia (CLL) is variable. In aggressive disease, the CLL cells usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H)) and the 70-kD zeta-associated protein (ZAP-70), whereas in indolent disease, the CLL cells usually express mutated IgV(H) but lack expression of ZAP-70. METHODS: We evaluated the CLL B cells from 307 patients with CLL...

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Share to B-Lymphocytes
Share to Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Proportional Hazards Models

Share to Protein-Tyrosine Kinases

Share to Receptors, Antigen, T-Cell

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 15329427
DOI: 10.1056/NEJMoa040857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.PMID 15329427Read ↗

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