Article
Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.
Blood - 15 Jun 2003
Tobin Gerard, Thunberg Ulf, Johnson Anna, Eriksson Inger, Söderberg Ola, Karlsson Karin, Merup Mats, Juliusson Gunnar, Vilpo Juhani, Enblad Gunilla, Sundström Christer, Roos Göran, Rosenquist Richard
Abstract excerpt
The immunoglobulin variable heavy chain (IgVH) gene mutation status is an important prognostic factor in chronic lymphocytic leukemia (CLL), since cases with mutated VH genes show significantly longer survival than unmutated cases. Recently, we reported a preferential use of the VH3-21 gene in mutated CLL and showed that mutated VH3-21 cases had an inferior overall survival compared with other mutated CLL. In...
Topics
- Amino Acid Sequence
- Complementarity Determining Regions
- Conserved Sequence
- Epitopes
- Gene Rearrangement
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains