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Article

Integrated analysis of IGHV rearrangements and cytogenetic abnormalities in a large chronic lymphocytic leukemia cohort (CLL-POL1).

BMC cancer - 24 Jun 2026

Własiuk Paulina, Szelest Monika, Paziewska Magdalena, Karczmarczyk Agnieszka, Czekalska Sylwia, Zawada Magdalena, Hut Malwina, Przybyszewski Oskar, Soin Michał, Wojtaszewska Marzena, Pępek Monika, Kwak Agnieszka, Pokrywka Małgorzata, Wójcik Piotr, Leszczyńska Aleksandra, Bukowicz Justyna, Szyca Wiktoria, Nowak-Ozimek Ewelina, Kowalik Artur, Borg Katarzyna, Makuch-Łasica Hanna, Wojtas Magdalena, Solarska Iwona, Jaskuła Emilia, Sobczyńska-Konefał Anna, Paruzel Klaudia, Chudy Agnieszka, Wawrzyniak Ewa, Stokłosa Tomasz, Giannopoulos Krzysztof

Abstract excerpt

The somatic hypermutation (SHM) status of immunoglobulin heavy-chain variable region gene (IGHV) is a well-established prognostic factor in chronic lymphocytic leukemia (CLL). We analyzed clonotypic IGHV-IGHD-IGHJ rearrangements in 4,251 newly diagnosed CLL patients in Poland (CLL-POL1), representing the largest national cohort to date. In total, 4,328 productive rearrangements were evaluated, of which 93%...

Read the complete abstract on PubMed

Topics

Humans
Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chromosome Aberrations

Immunoglobulin Variable Region

Immunoglobulin Heavy Chains

Female

Male

Somatic Hypermutation, Immunoglobulin

Aged

Middle Aged

Mutation

Aged, 80 and over

Prognosis

Cohort Studies

Poland

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42343292
DOI: 10.1186/s12885-026-16382-8
PMCID: PMC13551863

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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