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Article

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes.

Blood - 1 Mar 2006

Kienle Dirk, Benner Axel, Kröber Alexander, Winkler Dirk, Mertens Daniel, Bühler Andreas, Seiler Till, Jäger Ulrich, Lichter Peter, Döhner Hartmut, Stilgenbauer Stephan

Abstract excerpt

The mutation status and usage of specific VH genes such as V3-21 and V1-69 are potentially independent pathogenic and prognostic factors in chronic lymphocytic leukemia (CLL). To investigate the role of antigenic stimulation, we analyzed the expression of genes involved in B-cell receptor (BCR) signaling/activation, cell cycle, and apoptosis control in CLL using these specific VH genes compared to VH mutated...

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Topics

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Share to Cell Cycle
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphocyte Activation

Share to Neoplasm Proteins

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 16322480
DOI: 10.1182/blood-2005-04-1483

Genes

BCR
CCND2
CDK4
BAX
BLNK
FOS
SYK
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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