Article
Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling.
Archives of biochemistry and biophysics - 1 Feb 2006
Basile Maria, Lin Ridwan, Kabbani Nadine, Karpa Kelly, Kilimann Manfred, Simpson Ian, Kester Mark
Abstract excerpt
Paralemmin is a novel lipid-anchored protein, which is highly expressed in neuronal plasma membranes. In this study, we demonstrate that paralemmin specifically interacts with the third intracellular loop of the D3 dopamine receptor. Utilizing co-immunoprecipitation and glutathione-S-transferase (GST) pulldown strategies, we demonstrate that paralemmin interacts exclusively with D3, but not D2 or D4 dopamine...
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