Article
SH3 ligands in the dopamine D3 receptor.
Cellular signalling - 1 Jun 2001
Oldenhof J, Ray A, Vickery R, Van Tol H H
Abstract excerpt
It has recently been observed that G protein-coupled receptors (GPCRs) can interact with SH3 domains through polyproline motifs. These interactions appear to be involved in receptor internalization and MAPK signalling. Here we report that the third cytoplasmic loop of the dopamine D3 receptor can interact in vitro with the adaptor protein Grb2. While the amino- and carboxy-terminal SH3 domains of Grb2 separately...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
