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Commentary on "Novel Interaction of the Dopamine D2 Receptor and the Ca2+ Binding Protein S100B: Role in D2 Receptor Function".

Molecular pharmacology - 1 Aug 2021

Lee Hun-Joo, Rodriguez-Contreras Dayana, Neve Kim A

Abstract excerpt

We previously proposed that the dopamine D2 receptor-interacting protein S100B binds to a putative S100B-binding motif at residues R233-L240 toward the N terminus of the third intracellular loop. We used in vitro pull-down assays with FLAG-tagged fragments of the rat dopamine D2 receptor third intracellular loop (D2-IC3) and in vitro-synthesized S100B to evaluate this hypothesis. Our results indicate that the...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Dopamine D2

Share to S100 Calcium Binding Protein beta Subunit

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Identifiers

PMID: 34045267
DOI: 10.1124/molpharm.121.000284
PMCID: PMC8382258

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