Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin.

Biological chemistry - 1 Oct 2001

Grosskreutz Y, Hermann A, Kins S, Fuhrmann J C, Betz H, Kneussel M

Abstract excerpt

The brain-specific GDP/GTP exchange factor collybistin interacts with the receptor-anchoring protein gephyrin and activates the Rho-like GTPase Cdc42, which is known to regulate actin cytoskeleton dynamics. Alternative splicing creates two collybistin variants, I and II. In coexpression experiments, collybistin II has been shown to induce the formation of submembraneous gephyrin aggregates which cluster with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Carrier Proteins
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Protein Conformation

Share to Receptors, GABA-A

Share to Receptors, Glycine

Share to Rho Guanine Nucleotide Exchange Factors

Source

Identifiers

PMID: 11727829
DOI: 10.1515/BC.2001.179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin.PMID 11727829Read ↗

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.Semantic proximity Read ↗

A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin.Semantic proximity Read ↗

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.Semantic proximity Read ↗

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.Semantic proximity Read ↗

Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia.Semantic proximity Read ↗

Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site.Semantic proximity Read ↗

A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition.Semantic proximity Read ↗

Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein.Semantic proximity Read ↗

Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1Semantic proximity Read ↗

The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton.Semantic proximity Read ↗

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.Semantic proximity Read ↗

Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.