Article
Regulation of dopamine D(1) receptor trafficking by protein kinase A-dependent phosphorylation.
Molecular pharmacology - 1 Apr 2002
Mason John N, Kozell Laura B, Neve Kim A
Abstract excerpt
The aim of this study was to use pharmacological inhibition of protein kinase A and mutation of potential protein kinase A phosphorylation sites to determine the role of protein kinase A-catalyzed phosphorylation of the dopamine D(1) receptor in agonist-stimulated desensitization and internalization of the receptor. To facilitate purification and imaging of the D(1) receptor, we attached a polyhistidine tag to...
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