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Article

A dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin binding.

Molecular pharmacology - 1 Jan 2009

Lan Hongxiang, Liu Yong, Bell Michal I, Gurevich Vsevolod V, Neve Kim A

Abstract excerpt

Arrestins mediate G protein-coupled receptor desensitization, internalization, and signaling. Dopamine D(2) and D(3) receptors have similar structures but distinct characteristics of interaction with arrestins. The goals of this study were to compare arrestin-binding determinants in D(2) and D(3) receptors other than phosphorylation sites and to create a D(2) receptor that is deficient in arrestin binding. We...

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Identifiers

PMID: 18809670
DOI: 10.1124/mol.108.050534
PMCID: PMC2606918

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Source receipt: pubmed, retrieved 7 Sept 2026.

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