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Article

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jun 2004

Harvey Kirsten, Duguid Ian C, Alldred Melissa J, Beatty Sarah E, Ward Hamish, Keep Nicholas H, Lingenfelter Sue E, Pearce Brian R, Lundgren Johan, Owen Michael J, Smart Trevor G, Lüscher Bernhard, Rees Mark I, Harvey Robert J

Abstract excerpt

Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin. We report the characterization of several new variants of collybistin, which are created by alternative splicing of exons encoding an N-terminal src homology 3 (SH3) domain and three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15215304
DOI: 10.1523/JNEUROSCI.1184-04.2004
PMCID: PMC6729214

Genes

ARHGEF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.PMID 15215304Read ↗

Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin.Semantic proximity Read ↗

Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses.Semantic proximity Read ↗

A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin.Semantic proximity Read ↗

Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia.Semantic proximity Read ↗

PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.Semantic proximity Read ↗

Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site.Semantic proximity Read ↗

Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit.Semantic proximity Read ↗

Autism spectrum disorder in females with ARHGEF9 alterations and a random pattern of X chromosome inactivation.Semantic proximity Read ↗

Loss-of-function mutation of collybistin is responsible for X-linked mental retardation associated with epilepsy.Semantic proximity Read ↗

Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversitySemantic proximity Read ↗

A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition.Semantic proximity Read ↗

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin.Semantic proximity Read ↗

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