Article
Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail.
The Journal of biological chemistry - 4 Mar 2005
Murdoch Hannah, Feng Gui-Jie, Bächner Dietmar, Ormiston Laura, White Julia H, Richter Dietmar, Milligan Graeme
Abstract excerpt
In mice genetic ablation of expression of either melanin-concentrating hormone or the melanin-concentrating hormone-1 receptor results in alterations in energy metabolism and a lean phenotype. There is thus great interest in the function and regulation of this receptor. Using the yeast two-hybrid system we identified an interaction of the actin- and intermediate filament-binding protein periplakin with the...
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