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Article

Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling.

Molecular pharmacology - 1 Jul 2012

Simon Violaine, Oner Sukru S, Cohen-Tannoudji Joelle, Tobin Andrew B, Lanier Stephen M

Abstract excerpt

The proto-oncogene and inhibitor of protein phosphatase 2A (PP2A), SET, interacts with the third intracellular loop of the M3 muscarinic receptor (M3-MR), and SET knockdown with small interfering RNA (siRNA) in Chinese hamster ovary (CHO) cells augments M3-MR signaling. However, the mechanism of this action of SET on receptor signaling has not been defined, and we initiated studies to address this question....

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Source

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Identifiers

PMID: 22466417
DOI: 10.1124/mol.111.075523
PMCID: PMC3382831

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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