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Article

A multimarker regression-based test of linkage for affected sib-pairs at two linked loci.

Genetic epidemiology - 1 Apr 2006

Barber Mathew J, Todd John A, Cordell Heather J

Abstract excerpt

We address the analytical problem of evaluating the evidence for linkage at a test locus while taking into account the effect of a known linked disease locus. The method we propose is a multimarker regression approach that models the identity-by-descent states for affected sib-pairs at a series of linked markers in terms of the identity-by-descent state at the known disease locus. Our method allows analysis to be...

Topics

Chromosome Mapping
Diabetes Mellitus, Type 1
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Male
Models, Theoretical
Siblings

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Identifiers

PMID: 16385470
DOI: 10.1002/gepi.20137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16385470-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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