Multilocus linkage tests based on affected relative pairs.

doi:10.1086/302847

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Article

Multilocus linkage tests based on affected relative pairs.

American journal of human genetics - 1 Apr 2000

Cordell H J, Wedig G C, Jacobs K B, Elston R C

Abstract excerpt

For complex diseases, recent interest has focused on methods that take into account joint effects at interacting loci. Conditioning on effects of disease loci at known locations can lead to increased power to detect effects at other loci. Moreover, use of joint models allows investigation of the...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human
Computer Simulation
Diabetes Mellitus, Type 1
Epistasis, Genetic
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
HLA Antigens
Humans
Likelihood Functions
Male
Matched-Pair Analysis
Models, Genetic
Nuclear Family

Source

Open in PubMed Open full text

Identifiers

PMID: 10729111
DOI: 10.1086/302847
PMCID: PMC1288194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10729111-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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