Article
Multilocus linkage tests based on affected relative pairs.
American journal of human genetics - 1 Apr 2000
Cordell H J, Wedig G C, Jacobs K B, Elston R C
Abstract excerpt
For complex diseases, recent interest has focused on methods that take into account joint effects at interacting loci. Conditioning on effects of disease loci at known locations can lead to increased power to detect effects at other loci. Moreover, use of joint models allows investigation of the etiologic mechanisms that may be involved in the disease. Here we present a method for simultaneous analysis of the...
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