Article
Evaluation of fine mapping strategies for a multifactorial disease locus: systematic linkage and association analysis of IDDM1 in the HLA region on chromosome 6p21.
Human molecular genetics - 22 May 2000
Herr M, Dudbridge F, Zavattari P, Cucca F, Guja C, March R, Campbell R D, Barnett A H, Bain S C, Todd J A, Koeleman B P
Abstract excerpt
The positional cloning of multifactorial disease genes is a major challenge in human genetics. We have therefore empirically tested the utility of the available polymorphic microsatellite map to locate the already identified type 1 diabetes locus IDDM1 (sibling risk/population prevalence ratio lambda(s)= 2.7) within a 14 Mb region of chromosome 6p21 linked to disease. In a two-stage approach to fine mapping,...
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