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Article

Affected sibpair linkage tests for multiple linked susceptibility genes.

Genetic epidemiology - 1 Jan 1997

Farrall M

Abstract excerpt

Genome-wide searches for susceptibility genes using pairs of affected siblings are being undertaken to dissect out individual polygenes that contribute to human multifactorial disease. Efficient identity-by-descent (IBD)-based sibpair linkage tests are available that test individual markers or maps of linked markers for linkage to a single putative susceptibility gene. In order to assess the support for linkage...

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PMID: 9129957
DOI: 10.1002/(SICI)1098-2272(1997)14:2<103::AID-GEPI1>3.0.CO;2-8

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