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Article

Affected sibpair linkage tests for multiple linked susceptibility genes.

Genetic epidemiology - 1 Jan 1997

Farrall M

Abstract excerpt

Genome-wide searches for susceptibility genes using pairs of affected siblings are being undertaken to dissect out individual polygenes that contribute to human multifactorial disease. Efficient identity-by-descent (IBD)-based sibpair linkage tests are available that test individual markers or maps of linked markers for linkage to a single putative susceptibility gene. In order to assess the support for linkage...

Topics

Chromosome Mapping
Computer Simulation
Genetic Linkage
Genetic Predisposition to Disease
Humans
Lod Score
Meiosis
Models, Statistical
Pedigree

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9129957
DOI: 10.1002/(SICI)1098-2272(1997)14:2<103::AID-GEPI1>3.0.CO;2-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9129957-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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