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Article

A robust identity-by-descent procedure using affected sib pairs: multipoint mapping for complex diseases.

Human heredity - 1 Jan 2001

Liang K Y, Chiu Y F, Beaty T H

Abstract excerpt

Multipoint linkage analysis is a powerful tool to localize susceptibility genes for complex diseases. However, the conventional lod score method relies critically on the correct specification of mode of inheritance for accurate estimation of gene position. On the other hand, allele-sharing methods, as currently practiced, are designed to test the null hypothesis of no linkage rather than estimate the location of...

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PMID: 11096273
DOI: 10.1159/000022961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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