A robust identity-by-descent procedure using affected sib pairs: multipoint mapping for complex diseases.

doi:10.1159/000022961

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Article

A robust identity-by-descent procedure using affected sib pairs: multipoint mapping for complex diseases.

Human heredity - 1 Jan 2001

Liang K Y, Chiu Y F, Beaty T H

Abstract excerpt

Multipoint linkage analysis is a powerful tool to localize susceptibility genes for complex diseases. However, the conventional lod score method relies critically on the correct specification of mode of inheritance for accurate estimation of gene position. On the other hand, allele-sharing method...

Topics

Chromosome Mapping
Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Humans
Models, Genetic
Models, Statistical
Nuclear Family

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