Affected-sib-pair test for linkage based on constraints for identical-by-descent distributions corresponding to disease models with imprinting.

Abstract excerpt

Holmans' possible triangle test for affected sib pairs has proven to be a powerful tool for linkage analysis. This test is a likelihood-ratio test for which maximization is restricted to the set of possible sharing probabilities. Here, we extend the possible triangle test to take into account genomic imprinting, which is also known as parent-of-origin effect. While the classical test without imprinting looks at...

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• Share to Alleles
• Share to Genetic Heterogeneity
• Share to Genetic Linkage