Article
Affected-sib-pair test for linkage based on constraints for identical-by-descent distributions corresponding to disease models with imprinting.
Genetic epidemiology - 1 May 2004
Knapp Michael, Strauch Konstantin
Abstract excerpt
Holmans' possible triangle test for affected sib pairs has proven to be a powerful tool for linkage analysis. This test is a likelihood-ratio test for which maximization is restricted to the set of possible sharing probabilities. Here, we extend the possible triangle test to take into account genomic imprinting, which is also known as parent-of-origin effect. While the classical test without imprinting looks at...
Topics
- Alleles
- Genetic Heterogeneity
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Humans
- Likelihood Functions
- Lod Score
- Models, Genetic
- Models, Statistical