Article
Accurate inference of relationships in sib-pair linkage studies.
American journal of human genetics - 1 Aug 1997
Boehnke M, Cox N J
Abstract excerpt
Relative-pair designs are routinely employed in linkage studies of complex genetic diseases and quantitative traits. Valid application of these methods requires correct specification of the relationships of the pairs. For example, within a sibship, presumed full sibs actually might be MZ twins, h...
Topics
- Alleles
- Diabetes Mellitus, Type 2
- Family
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Humans
- Likelihood Functions
- Markov Chains
- Models, Genetic
- Reproducibility of Results