Article
Multipoint analysis using affected sib pairs: incorporating linkage evidence from unlinked regions.
Genetic epidemiology - 1 Sept 2001
Liang K Y, Chiu Y F, Beaty T H, Wjst M
Abstract excerpt
In this paper, we proposed a multipoint method to assess evidence of linkage to one region by incorporating linkage evidence from another region. This approach uses affected sib pairs in which the number of alleles shared identical by descent (IBD) is the primary statistic. This generalized estimating equation (GEE) approach is robust in that no assumption about the mode of inheritance is required, other than...
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