Multipoint analysis using affected sib pairs: incorporating linkage evidence from unlinked regions.

doi:10.1002/gepi.1021

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Article

Multipoint analysis using affected sib pairs: incorporating linkage evidence from unlinked regions.

Genetic epidemiology - 1 Sept 2001

Liang K Y, Chiu Y F, Beaty T H, Wjst M

Abstract excerpt

In this paper, we proposed a multipoint method to assess evidence of linkage to one region by incorporating linkage evidence from another region. This approach uses affected sib pairs in which the number of alleles shared identical by descent (IBD) is the primary statistic. This generalized estim...

Topics

Asthma
Chromosome Mapping
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 6
Genetic Linkage
Genetic Predisposition to Disease
Humans
Models, Genetic
Models, Statistical
Nuclear Family

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