Article
Simultaneous localization of two linked disease susceptibility genes.
Genetic epidemiology - 1 Jan 2005
Biernacka Joanna M, Sun Lei, Bull Shelley B
Abstract excerpt
For diseases with complex genetic etiology, more than one susceptibility gene may exist in a single chromosomal region. Extending the work of Liang et al. ([2001] Hum. Hered. 51:64-78), we developed a method for simultaneous localization of two susceptibility genes in one region. We derived an expression for expected allele sharing of an affected sib pair (ASP) at each point across a chromosomal segment...
Topics
- Algorithms
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Computer Simulation
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Quantitative Trait Loci