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Article

CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005

Levine Amir A, Guan Zhonghui, Barco Angel, Xu Shiqin, Kandel Eric R, Schwartz James H

Abstract excerpt

Remodeling chromatin is essential for cAMP-regulated gene expression, necessary not only for development but also for memory storage and other enduring mental states. Histone acetylation and deacetylation mediate long-lasting forms of synaptic plasticity in Aplysia as well as cognition in mice. Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-fos

Source

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Identifiers

PMID: 16380431
DOI: 10.1073/pnas.0509735102
PMCID: PMC1323217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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