Article
Blockade of cyclic AMP-responsive element DNA binding in the brain of CREB delta/alpha mutant mice.
Neuroreport - 3 Aug 2000
Pandey S C, Mittal N, Silva A J
Abstract excerpt
The cAMP-responsive element binding protein (CREB) gene transcription factor has been implicated in the synaptic plasticity and memory. Here, we investigated the mechanisms of CREB and/or cyclic AMP-responsive element modulatory protein (CREM) binding to CRE sites in brain tissues. CRE-DNA binding was determined in nuclear extracts obtained from the several brain structures of wild-type and CREB delta/alpha...
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