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Article

Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine.

Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2010

McPherson Cameron S, Mantamadiotis Theo, Tan Seong-Seng, Lawrence Andrew J

Abstract excerpt

Transcriptional changes in neurons underpin the long-lived cellular response to environmental stimuli, and cAMP-responsive element-binding protein (CREB1) has been implicated in this process. Exposure to psychostimulants such as cocaine results in persistent neuronal plasticity in cortical circuitry that likely modulates the motivation to use the drug again. To examine whether CREB1 in cortical glutamatergic...

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Identifiers

PMID: 19666831
DOI: 10.1093/cercor/bhp159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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