Article
Prefrontal consolidation supports the attainment of fear memory accuracy.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Aug 2014
Vieira Philip A, Lovelace Jonathan W, Corches Alex, Rashid Asim J, Josselyn Sheena A, Korzus Edward
Abstract excerpt
The neural mechanisms underlying the attainment of fear memory accuracy for appropriate discriminative responses to aversive and nonaversive stimuli are unclear. Considerable evidence indicates that coactivator of transcription and histone acetyltransferase cAMP response element binding protein (CREB) binding protein (CBP) is critically required for normal neural function. CBP hypofunction leads to severe...
Topics
- Acoustic Stimulation
- Animals
- Auditory Perception
- CREB-Binding Protein
- Conditioning, Classical
- Cyclic AMP Response Element-Binding Protein
- Discrimination, Psychological
- Electroshock
- Fear
- Foot
- Memory
- Mice, Inbred C57BL
- Motor Activity