Article
Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine.
Brain research - 25 Apr 2003
Peakman M-C, Colby C, Perrotti L I, Tekumalla P, Carle T, Ulery P, Chao J, Duman C, Steffen C, Monteggia L, Allen M R, Stock J L, Duman R S, McNeish J D, Barrot M, Self D W, Nestler E J, Schaeffer E
Abstract excerpt
Administration of cocaine induces the Fos family of transcription factors in the striatum, including the nucleus accumbens (NAc), a brain region important for the rewarding effects of addictive drugs. Several Fos proteins are induced acutely by cocaine, with stable isoforms of DeltaFosB predominating after chronic drug administration. However, it has been difficult to study the functional consequences of these...
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