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Article

Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2008

Bilbao Ainhoa, Parkitna Jan Rodriguez, Engblom David, Perreau-Lenz Stéphanie, Sanchis-Segura Carles, Schneider Miriam, Konopka Witold, Westphal Magdalena, Breen Gerome, Desrivieres Sylvane, Klugmann Matthias, Guindalini Camila, Vallada Homero, Laranjeira Ronaldo, de Fonseca Fernando Rodriguez, Schumann Gunter, Schütz Günther, Spanagel Rainer

Abstract excerpt

The persistent nature of addiction has been associated with activity-induced plasticity of neurons within the striatum and nucleus accumbens (NAc). To identify the molecular processes leading to these adaptations, we performed Cre/loxP-mediated genetic ablations of two key regulators of gene expr...

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Identifiers

PMID: 19001277
DOI: 10.1073/pnas.0803959105
PMCID: PMC2582267

Genes

CAMK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19001277-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.PMID 19001277Read ↗

Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice.Semantic proximity Read ↗

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