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Article

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2018

Hamilton Peter J, Burek Dominika J, Lombroso Sonia I, Neve Rachael L, Robison Alfred J, Nestler Eric J, Heller Elizabeth A

Abstract excerpt

Chronic social defeat stress regulates the expression of Fosb in the nucleus accumbens (NAc) to promote the cell-type-specific accumulation of ΔFosB in the two medium spiny neuron (MSN) subtypes in this region. ΔFosB is selectively induced in D1-MSNs in the NAc of resilient mice, and in D2-MSNs of susceptible mice. However, little is known about the consequences of such selective induction, particularly in...

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PMID: 28462942
DOI: 10.1038/npp.2017.88
PMCID: PMC5729576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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