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Article

Dual roles for Mcm10 in DNA replication initiation and silencing at the mating-type loci.

Molecular biology reports - 1 Dec 2005

Douglas Nancy L, Dozier Samantha K, Donato Justin J

Abstract excerpt

Recent studies linking DNA replication proteins to transcriptional silencing suggest that some of the same mechanisms that facilitate the initiation of replication at origins might be involved in establishing repressed chromatin at silencer elements. Our ongoing studies of several mutants of the replication initiation factor Mcm10 of budding yeast revealed an associated defect in the production of mating type...

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Topics

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Share to Genes, Mating Type, Fungal
Share to Histone Deacetylases
Share to Minichromosome Maintenance Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pheromones

Share to Silencer Elements, Transcriptional

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Source

Identifiers

PMID: 16328881
DOI: 10.1007/s11033-005-2312-x

Genes

MCM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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