Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome loss, hyperrecombination, and cell cycle arrest in a yeast mcm1 mutant.

Molecular biology of the cell - 1 Sept 1992

Elble R, Tye B K

Abstract excerpt

The original mcm1-1 mutant was identified by its inability to propagate minichromosomes in an ARS-specific manner, suggesting that it is defective in the initiation of DNA synthesis at ARSs. This mutant is also defective in expression of alpha-mating-type-specific genes. Further genetic and biochemical studies confirmed that Mcm1 is a transcription factor that mediates the transcriptional regulation of a number...

Topics

Cell Cycle
Chromosomes, Fungal
DNA Replication
DNA-Binding Proteins
Genes, Fungal
Genes, Mating Type, Fungal
Minichromosome Maintenance 1 Protein
Mutation
Recombination, Genetic
Saccharomyces cerevisiae
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 1421579
DOI: 10.1091/mbc.3.9.971
PMCID: PMC275658

Genes

MCM2
MCM3
MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1421579-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome loss, hyperrecombination, and cell cycle arrest in a yeast mcm1 mutant.PMID 1421579Read ↗

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.Semantic proximity Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.Semantic proximity Read ↗

Functional domains of the yeast transcription/replication factor MCM1.Semantic proximity Read ↗

The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome.Semantic proximity Read ↗

Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1.Semantic proximity Read ↗

The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP), Mcb1, regulates MCM function during prereplicative complex formation in DNA replication.Semantic proximity Read ↗

Minichromosome maintenance as a genetic assay for defects in DNA replication.Semantic proximity Read ↗

The mcm2-1 mutation of yeast causes DNA damage with a RAD9 requirement for repair.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.Semantic proximity Read ↗

A 61-kb ring chromosome shows an ARS-dependent increase in its mitotic stability in the mcm2 mutant of yeast.Semantic proximity Read ↗

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.