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Article

Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae.

Genetics - 1 Oct 2005

Liachko Ivan, Tye Bik K

Abstract excerpt

Mcm10 is an essential protein that participates in both the initiation and the elongation of DNA replication. In this study we demonstrate a role for Mcm10 in the maintenance of heterochromatic silencing at telomeres and HM loci of budding yeast. Two mcm10 mutants drastically reduce silencing of both URA3 and ADE2 reporter genes integrated into these silent loci. When exposed to alpha-factor, mcm10 mutant cells...

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Share to Chromosomal Proteins, Non-Histone
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Share to Mating Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Minichromosome Maintenance Proteins

Share to Silencer Elements, Transcriptional

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

Open in PubMed Open full text

Identifiers

PMID: 16085704
DOI: 10.1534/genetics.105.042333
PMCID: PMC1456767

Genes

MCM10
MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae.PMID 16085704Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

Dual roles for Mcm10 in DNA replication initiation and silencing at the mating-type loci.Semantic proximity Read ↗

A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.Semantic proximity Read ↗

Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.Semantic proximity Read ↗

Saccharomyces cerevisiae linker histone Hho1p functionally interacts with core histone H4 and negatively regulates the establishment of transcriptionally silent chromatin.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

γH2A is a component of yeast heterochromatin required for telomere elongation.Semantic proximity Read ↗

A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae.Semantic proximity Read ↗

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