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Article

The role of the carboxyterminal domain of RNA polymerase II in regulating origins of DNA replication in Saccharomyces cerevisiae.

Genetics - 1 Nov 2002

Gauthier Laura, Dziak Renata, Kramer David J H, Leishman David, Song Xiaomin, Ho Jason, Radovic Maja, Bentley David, Yankulov Krassimir

Abstract excerpt

MCM (minichromosome maintenance) proteins function as a replication licensing factor (RLF-M), which contributes to limiting initiation of DNA replication to once per cell cycle. In the present study we show that a truncation of the pol II CTD in a S. cerevisiae strain harboring a mutation in mcm5 partially reverses its ts phenotype and improves maintenance of CEN/ARS minichromosomes. We correlate this phenotype...

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Identifiers

PMID: 12454060
DOI: 10.1093/genetics/162.3.1117
PMCID: PMC1462328

Genes

RLF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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