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Article

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.

British journal of pharmacology - 1 Jul 2003

Milnes James T, Crociani Olivia, Arcangeli Annarosa, Hancox Jules C, Witchel Harry J

Abstract excerpt

1. Pharmacological blockade of the Human ether-a-go-go related gene (HERG) potassium channel is commonly linked with acquired long QT syndrome and associated proarrhythmia. The objectives of this study were (i) to identify and characterise any inhibitory action on HERG of the selective-serotonin...

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Source

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Identifiers

PMID: 12839862
DOI: 10.1038/sj.bjp.0705335
PMCID: PMC1573929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12839862-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.PMID 12839862Read ↗

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Molecular Basis for state-dependent drug block of Kv11.1 (HERG) potassium channelsSemantic proximity Read ↗

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.Semantic proximity Read ↗

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.Semantic proximity Read ↗

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The evolutionarily conserved residue A653 plays a key role in HERG channel closing.Semantic proximity Read ↗

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656.Semantic proximity Read ↗

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