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Article

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.

Journal of molecular and cellular cardiology - 1 Jan 2006

Ridley John M, Milnes James T, Hancox Jules C, Witchel Harry J

Abstract excerpt

Human ether-à-go-go-related gene (HERG) encodes the alpha-subunit of channels carrying the cardiac rapid delayed K+ current (Ikr), which is a major determinant of the duration of ventricular action potentials (APs) and of the QT interval. This study investigated the effects on HERG channel current (IHERG) of clemastine, a "conventional" antihistamine that has been associated with delayed ventricular...

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Source

Identifiers

PMID: 16288909
DOI: 10.1016/j.yjmcc.2005.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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