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Article

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.

Biochemical and biophysical research communications - 9 Apr 2010

Hong Hee-Kyung, Park Mi-Hyeong, Lee Byung Hoon, Jo Su-Hyun

Abstract excerpt

Desipramine is a tricyclic antidepressant for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes. Since blockade of cardiac human ether-a-go-go-related gene (hERG) channels is an important cause of acquired long QT syndrome, we investigated the acute effects of desipramine on hERG channels to determine the electrophysiological basis for its pro-arrhythmic potential. We...

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Source

Identifiers

PMID: 20211602
DOI: 10.1016/j.bbrc.2010.03.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.PMID 20211602Read ↗

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Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.Semantic proximity Read ↗

Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656.Semantic proximity Read ↗

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Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.Semantic proximity Read ↗

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