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Article

H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.

Pharmacological research - 1 Nov 2009

Jo Su-Hyun, Hong Hee-Kyung, Chong Seon Ha, Lee Hui Sun, Choe Han

Abstract excerpt

Promethazine is a phenothiazine derivative with antihistaminic (H(1)), sedative, antiemetic, anticholinergic, and antimotion sickness properties that can induce QT prolongation, which may lead to torsades de pointes. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of the leading causes of acquired long QT syndrome, we investigated the acute effects of promethazine on hERG channels...

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Identifiers

PMID: 19497368
DOI: 10.1016/j.phrs.2009.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.PMID 19497368Read ↗

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.Semantic proximity Read ↗

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

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