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Article

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2007

Perry Matthew, Sachse Frank B, Sanguinetti Michael C

Abstract excerpt

Activation of human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediates cardiac action potential repolarization. Drugs that activate hERG1 channels represent a mechanism-based approach for the treatment of long QT syndrome, a disorder of cardiac repolarization associated with ventricular arrhythmia and sudden death. Here, we characterize the mechanisms of action and the molecular determinants for binding...

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Identifiers

PMID: 17693551
DOI: 10.1073/pnas.0703934104
PMCID: PMC1959467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.PMID 17693551Read ↗

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