Article
The hERG K(+) channel S4 domain L532P mutation: characterization at 37°C.
Biochimica et biophysica acta - 1 Oct 2011
Zhang Yi H, Colenso Charlotte K, Sessions Richard B, Dempsey Christopher E, Hancox Jules C
Abstract excerpt
hERG (human Ether-à-go-go Related Gene) is responsible for ion channels mediating rapid delayed rectifier potassium current, I(Kr), which is key to cardiac action potential repolarization. Gain-of-function hERG mutations give rise to the SQT1 variant of the Short QT Syndrome (SQTS). Reggae mutant zebrafish, with a S4 zERG mutation (Leucine499Proline; L499P), display arrhythmic features analogous to those seen in...
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