Article
Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.
Genes & development - 1 Oct 1998
Johnson R E, Torres-Ramos C A, Izumi T, Mitra S, Prakash S, Prakash L
Abstract excerpt
Abasic (AP) sites arise in DNA through spontaneous base loss and enzymatic removal of damaged bases. APN1 encodes the major AP-endonuclease of Saccharomyces cerevisiae. Human HAP1 (REF1) encodes the major AP endonuclease which, in addition to its role in DNA repair, functions as a redox regulator...
Topics
- Amino Acid Sequence
- Carbon-Oxygen Lyases
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- Fungal Proteins
- Genes, rev
- Humans
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins