Article
Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 1994
Kunz B A, Henson E S, Roche H, Ramotar D, Nunoshiba T, Demple B
Abstract excerpt
The loss of bases from cellular DNA occurs via both spontaneous and mutagen-induced reactions. The resulting apurinic/apyrimidinic (AP) sites are cytotoxic and mutagenic but are counteracted by repair initiated by AP endonucleases. Previously, in vitro and bacterial transfection studies suggested that AP sites often prompt insertion of dAMP residues during replication, the A-rule. Dissimilar results have been...
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