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Article

Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements.

Nucleic acids research - 10 Oct 2019

Elango Rajula, Osia Beth, Harcy Victoria, Malc Ewa, Mieczkowski Piotr A, Roberts Steven A, Malkova Anna

Abstract excerpt

Break induced replication (BIR) is a double strand break repair pathway that can promote genetic instabilities similar to those observed in cancer. Instead of a replication fork, BIR is driven by a migration bubble where asynchronous synthesis between leading and lagging strands leads to accumulation of single-stranded DNA (ssDNA) that promotes mutation. However, the details of the mechanism of mutagenesis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31392335
DOI: 10.1093/nar/gkz651
PMCID: PMC6765108

Genes

APOBEC3A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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