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Article

The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster.

The Journal of cell biology - 21 Nov 2005

Cullen C Fiona, Brittle Amy L, Ito Takashi, Ohkura Hiroyuki

Abstract excerpt

Conventional centrosomes are absent from the spindle in female meiosis in many species, but it is not clear how multiple chromosomes form one shared bipolar spindle without centrosomes. We identified a female sterile mutant in which each bivalent chromosome often forms a separate bipolar metaphase I spindle. Unlike wild type, prophase I chromosomes fail to form a single compact structure within the oocyte...

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Identifiers

PMID: 16301329
DOI: 10.1083/jcb.200508127
PMCID: PMC2171570

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The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster.PMID 16301329Read ↗

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