Article
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
2024-11-03
Abstract excerpt
In human oocytes, meiosis I is error-prone, causing early miscarriages and developmental disorders. The Aurora protein kinases are key regulators of chromosome segregation in mitosis and meiosis and their dysfunction is associated with aneuploidy. Oocytes contain three Aurora kinase (AURK) proteins, but only AURKA is necessary and sufficient to support oocyte meiosis in mice. However, the unique molecular contribu...
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Identifiers and source
- Literature Corpus work
- a7541830-394f-59d0-ac74-2569329a2662
- DOI
- 10.1101/2024.11.01.621527