Article
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.
Development (Cambridge, England) - 1 Oct 2008
Colombié Nathalie, Cullen C Fiona, Brittle Amy L, Jang Janet K, Earnshaw William C, Carmena Mar, McKim Kim, Ohkura Hiroyuki
Abstract excerpt
Spindle formation in female meiosis differs from mitosis in many animals, as it takes place independently of centrosomes, and the molecular requirements of this pathway remain to be understood. Here, we report two crucial roles of Incenp, an essential subunit of the chromosomal passenger complex (the Aurora B complex), in centrosome-independent spindle formation in Drosophila female meiosis. First, the initial...
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