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Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.

Developmental cell - 5 Dec 2016

Fernández-Álvarez Alfonso, Bez Cécile, O'Toole Eileen T, Morphew Mary, Cooper Julia Promisel

Abstract excerpt

Faithful genome propagation requires coordination between nuclear envelope (NE) breakdown, spindle formation, and chromosomal events. The conserved linker of nucleoskeleton and cytoskeleton (LINC) complex connects fission yeast centromeres and the centrosome, across the NE, during interphase. During meiosis, LINC connects the centrosome with telomeres rather than centromeres. We previously showed that loss of...

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Identifiers

PMID: 27889481
DOI: 10.1016/j.devcel.2016.10.021
PMCID: PMC5145006

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