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Article

The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes.

Journal of cell science - 1 Oct 2012

Loh Benjamin J, Cullen C Fiona, Vogt Nina, Ohkura Hiroyuki

Abstract excerpt

In Drosophila oocytes, after the completion of recombination, meiotic chromosomes form a compact cluster called the karyosome within the nucleus, and later assemble spindle microtubules without centrosomes. Although these oocyte-specific phenomena are also observed in humans, their molecular basis is not well understood. Here, we report essential roles for the conserved kinase SRPK in both karyosome formation and...

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Identifiers

PMID: 22854045
DOI: 10.1242/jcs.107979
PMCID: PMC3500864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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